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1350456-67-5

1350456-67-5 Structure

1350456-67-5 Structure
IdentificationBack Directory
[Name]

D-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
[CAS]

1350456-67-5
[Synonyms]

Fmoc-Val-D-Cit-PAB
D-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
[Molecular Formula]

C33H39N5O6
[MOL File]

1350456-67-5.mol
[Molecular Weight]

601.69
Chemical PropertiesBack Directory
[Boiling point ]

914.2±65.0 °C(Predicted)
[density ]

1.276±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

10.63±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC)[1].
[Biological Activity]

Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC)[1].
[IC 50]

Protease Cleavable Linker
[References]

[1]. Mondal D, et al. Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research. Tetrahedron Lett. 2018;59(40):3594-3599.
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