| Identification | Back Directory | [Name]
D-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | [CAS]
1350456-67-5 | [Synonyms]
Fmoc-Val-D-Cit-PAB
D-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | [Molecular Formula]
C33H39N5O6 | [MOL File]
1350456-67-5.mol | [Molecular Weight]
601.69 |
| Chemical Properties | Back Directory | [Boiling point ]
914.2±65.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.63±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-agent-conjugation (ADC)[1]. | [Biological Activity]
Fmoc-D-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC)[1]. | [IC 50]
Protease Cleavable Linker | [References]
[1]. Mondal D, et al. Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research. Tetrahedron Lett. 2018;59(40):3594-3599. |
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