| Identification | Back Directory | [Name]
Disuccinimidyl Sulfoxide | [CAS]
1351828-03-9 | [Synonyms]
Disuccinimidyl Sulfoxide
Propanoic acid, 3,3'-sulfinylbis-, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C14H16N2O9S | [MOL File]
1351828-03-9.mol | [Molecular Weight]
388.35 |
| Hazard Information | Back Directory | [Description]
Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns.1 The CID-induced separation of interlinked peptides in MS/MS permits MS3 analysis of single peptide chain fragment ions with defined modifications, due to DSSO remnants, for easy interpretation and unambiguous identification using existing database searching tools.1 | [Uses]
Disuccinimidyl sulfoxide (DSSO) is a mass spectrometry (MS)-cleavable cross-linker that is applicable for model peptides and proteins and a multisubunit protein complex. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites for identification of DSSO-cross-linked peptides based their distinct fragmentation patterns[1]. | [References]
1. Kao, A., Chiu, C.-l., Vellucci, D., et al. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes Mol. Cell. Proteomics 10(1),M110.002212(2011). |
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