| Identification | Back Directory | [Name]
Acetamide, N-[4-[[5-[3,4-dihydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methoxyphenyl]methoxy]phenyl]- | [CAS]
1352286-61-3 | [Synonyms]
Acetamide, N-[4-[[5-[3,4-dihydro-5-hydroxy-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methoxyphenyl]methoxy]phenyl]- | [Molecular Formula]
C31H27N3O5 | [MOL File]
1352286-61-3.mol | [Molecular Weight]
521.56 |
| Hazard Information | Back Directory | [Uses]
NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC50 values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer[1]. | [References]
[1] Sarkar R, et al. An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers. J Clin Endocrinol Metab. 2024 Aug 13;109(9):2306-2316. DOI:10.1210/clinem/dgae114 |
|
|