| Identification | Back Directory | [Name]
2H-Indazol-3-amine, 2-ethyl-N-[4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-thiazolyl]-4,5,6,7-tetrahydro- | [CAS]
1353570-40-7 | [Synonyms]
γ-Secretase modulator 13
2H-Indazol-3-amine, 2-ethyl-N-[4-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-thiazolyl]-4,5,6,7-tetrahydro- | [Molecular Formula]
C22H23FN6S | [MOL File]
1353570-40-7.mol | [Molecular Weight]
422.52 |
| Hazard Information | Back Directory | [Uses]
γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease[1]. | [References]
[1] Kevin D Rynearson, et al. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 Nov 15;28(22):115734. DOI:10.1016/j.bmc.2020.115734 |
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