| Identification | Back Directory | [Synonyms]
TRPM4 inhibitor 8
NMDAR/TRPM4 inhibitor 8
NMDAR/TRPM4-IN-2 (free base)
NMDAR/TRPM4 inhibitor 8 (Compound 8)
N*1*-(3-BroMo-benzyl)-N*1*-ethyl-ethane-1,2-diaMine
N'-[(3-bromophenyl)methyl]-N'-ethylethane-1,2-diamine |
| Chemical Properties | Back Directory | [Boiling point ]
300.6±22.0 °C(Predicted) | [density ]
1.293±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Liquid | [pka]
9.56±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1]. | [IC 50]
NMDA Receptor | [storage]
Store at -20°C | [References]
[1] Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302. DOI:10.1126/science.aay3302 |
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| Company Name: |
Henan Alfachem Co.,Ltd.
|
| Tel: |
0371-55051623 18137891487 |
| Website: |
www.chemicalbook.com/supplier/14555231/ |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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