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135722-27-9

135722-27-9 Structure

135722-27-9 Structure
IdentificationBack Directory
[Name]

S 14671
[CAS]

135722-27-9
[Synonyms]

S 14671
N-[2-[4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]-2-thiophenecarboxamide
N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]thiophene-2-carboxamide
2-Thiophenecarboxamide, N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-
[Molecular Formula]

C22H25N3O2S
[MDL Number]

MFCD00905005
[MOL File]

135722-27-9.mol
[Molecular Weight]

395.52
Chemical PropertiesBack Directory
[Boiling point ]

646.7±55.0 °C(Predicted)
[density ]

1.225±0.06 g/cm3(Predicted)
[pka]

14.51±0.46(Predicted)
Hazard InformationBack Directory
[Description]

S-14671 is a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8). It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites.
[Uses]

S-14671 is a high-affinity 5-HT1A agonist (pKi=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc[1].
[IC 50]

5-HT1A Receptor: 9.3 (pKi)
[References]

[1] Millan MJ, et al. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. Eur J Pharmacol. 1991 Oct 15;203(2):319-22. DOI:10.1016/0014-2999(91)90734-8
135722-27-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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