| Identification | Back Directory | [Name]
6-aminotetralin-2,3-diol | [CAS]
13575-86-5 | [Synonyms]
ADTN hydrobromide
6-aminotetralin-2,3-diol
6,7-Dihydroxy-2-aminotetraline hydrobromide
Aminotetraline hydrobromide, 6,7-Dihydroxy-2-
6-Amino-5,6,7,8-tetrahydro-2,3-naphthalenediolhydrobromide
(+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthaleneHydrobromide | [Molecular Formula]
C10H13NO2 | [MDL Number]
MFCD00036982 | [MOL File]
13575-86-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
270-271 °C | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water (up to 25 mg/ml) | [form ]
solid | [color ]
Tan | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week. |
| Hazard Information | Back Directory | [Description]
6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2? Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce excitatory synaptic transmission in the nucleus accumbens by activating presynaptic dopamine receptors.4 | [Uses]
(+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide is a dopamine receptor agonist in Tribolium castaneum. | [References]
1) List et al. (1982), Striatal binding of 2-amino-6,7-[3H]dihydroxy-1,2,3,4-tetrahydronaphthalene to two dopaminergic sites distinguished by their low and high affinity for neuroleptics; J. Neurosci., 2 895
2) Templeton et al. (1982), Binding of [3H]ADTN to rat striatal membranes; Biochem. Pharmacol., 31 1629
3) Freedman et al. (1994), Expression and pharmacological characterization of the human D3 dopamine receptor; Curr. J. Pharmacol. Exp. Ther., 268 417
4) Nicola et al. (1996), Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors; J. Neurosci., 16 1591 |
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