| Identification | Back Directory | [Name]
PH 797804 | [CAS]
1358027-80-1 | [Synonyms]
(-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
Benzamide, 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethyl-, (3S)- | [Molecular Formula]
C22H19BrF2N2O3 | [MDL Number]
MFCD18251426 | [MOL File]
1358027-80-1.mol | [Molecular Weight]
477.3 |
| Chemical Properties | Back Directory | [Boiling point ]
593.2±50.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [solubility ]
Soluble to 50 mM in DMSO | [pka]
15.14±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
(S)-(-)-PH-797804 is an atropisomer of PH-797804 (P399155) which is a novel N-phenylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase known to exerts anti-inflammatory properties. | [Definition]
ChEBI: PH 797804 is a member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor and an anti-inflammatory agent. It is a member of benzamides, an organofluorine compound, a pyridone, an organobromine compound and an aromatic ether. | [IC 50]
p38α: 26 nM (IC50); p38β: 102 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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