| Identification | Back Directory | [Name]
IGF-I (24-41) | [CAS]
135861-49-3 | [Synonyms]
IGF-I (24-41)
IGF-I FRAG 24-41 HUMAN
INSULIN-LIKE GROWTH FACTOR I (24-41)
INSULIN-LIKE GROWTH FACTOR I FRAGMENT 24-41, HUMAN
TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR
H-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-
H-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH
H2N-TYR-PHE-ASN-LYS-PRO-THR-GLY-TYR-GLY-SER-SER-SER-ARG-ARG-ALA-PRO-GLN-THR-OH
L-Threonine, L-tyrosyl-L-phenylalanyl-L-asparaginyl-L-lysyl-L-prolyl-L-threonylglycyl-L-tyrosylglycyl-L-seryl-L-seryl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-prolyl-L-glutaminyl- | [Molecular Formula]
C88H133N27O28 | [MDL Number]
MFCD00076548 | [MOL File]
135861-49-3.mol | [Molecular Weight]
2017.16 |
| Chemical Properties | Back Directory | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
Solid | [color ]
White to off-white | [Sequence]
Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr |
| Hazard Information | Back Directory | [Uses]
IGF-I (24-41) (Insulin-like Growth Factor I (24-41)) is amino acids 24 to 41 fragment of IGF-I. IGF-I, a 70 aa polypeptide hormone, is a trophic factor for both neurons and glial cells. IGF-I is partly responsible for systemic growth hormone (GH) activities. IGF-I has anabolic, antioxidant, anti-inflammatory and cytoprotective actions. IGF-I (24-41) regulates somatic growth and behavioral development[1][2][3]. | [in vivo]
IGF-I (24-41) (ICV; 200 ng dose; 2 μL; postnatal days 2, 4, and 7) regulates somatic growth and behavioral development[2].
| Animal Model: | Mice of an outbred Swiss-derived strain (CD-l) weighing 30-33g (virgin males) or 28-30g (nulliparous females)[2] | | Dosage: | 200 ng dose; 2 μL | | Administration: | ICV; postnatal days (PND) 2, 4, and 7 | | Result: | Increased the rate of ultrasonic calls of the pups measured on PND8.
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| [References]
[1] Puche JE, et al. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012 Nov 14;10:224. DOI:10.1186/1479-5876-10-224
[2] D Santucci, et al. IGF-I and IGF-I24-41 but not IGF-I57-70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull. 1994;35(4):367-71. DOI:10.1016/0361-9230(94)90115-5
[3] Dan Meng, et al. Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med. 2007 Jun 1;42(11):1651-60. DOI:10.1016/j.freeradbiomed.2007.01.037 |
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