ChemicalBook--->CAS DataBase List--->1359627-33-0

1359627-33-0

1359627-33-0 Structure

1359627-33-0 Structure
IdentificationBack Directory
[Name]

P516-0475
[CAS]

1359627-33-0
[Synonyms]

P516-0475
[Molecular Formula]

C15H17N5O3
[MOL File]

1359627-33-0.mol
[Molecular Weight]

315.33
Chemical PropertiesBack Directory
[density ]

1.44±0.1 g/cm3(Predicted)
[pka]

11.05±0.20(Predicted)
Hazard InformationBack Directory
[Description]

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
[Uses]

P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2].
[References]

[1] Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293(3): 931-940. DOI:10.1074/jbc.M117.810994
[2] Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11(4):e0527922. DOI:10.1128/spectrum.05279-22
1359627-33-0 suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Company Name: TargetMol Chemicals Inc.
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Website: https://www.targetmol.cn/
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Website: http://www.synzest.com
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