| Identification | Back Directory | [Name]
ANNEXIN V | [CAS]
136107-94-3 | [Synonyms]
PAP-1
ANNEXIN V
ACE2 human
LIPOCORTIN V
SARS receptor
CALPHOSBINDIN I
ANNEXIN V (HUMAN)
Annexin V, Recombinant
Annexin V from human placenta
ANNEXIN V, HUMAN, RECOMBINANT
Angiotensin-converting enzyme 2
Annexin V FITC Conjugate from human placenta
Annexin V Cy3.18 Conjugate from human placenta
Annexin V Biotin Conjugate from human placenta | [Molecular Formula]
C21H18O5 | [MDL Number]
MFCD00162083 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
water: soluble | [form ]
buffered aqueous solution | [color ]
white | [biological source]
human placenta | [Water Solubility ]
water: soluble |
| Hazard Information | Back Directory | [Uses]
For detection of apoptotic cells by flow cytometry or fluorescence microscopy. | [Biochem/physiol Actions]
Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry. |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
amyjet
|
| Telephone: |
4006800868;027-59626688 18771149750 |
| Website: |
http://www.amyjet.com/ |
|