| Identification | Back Directory | [Name]
L-Leucine, 2,3,4,5,6-pentafluoro-D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-D-alanyl-L-histidyl-, methyl ester | [CAS]
136207-23-3 | [Synonyms]
BIM-26226
{D-F5 Phe}-Gln-Trp-{D-Ala}-Val-Ala-His-Leu-Ome
L-Leucine, 2,3,4,5,6-pentafluoro-D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-D-alanyl-L-histidyl-, methyl ester | [Molecular Formula]
C49H63F5N12O10 | [MOL File]
136207-23-3.mol | [Molecular Weight]
1075.09 |
| Chemical Properties | Back Directory | [Boiling point ]
1397.5±65.0 °C(Predicted) | [density ]
1.348±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.07±0.46(Predicted) | [color ]
White to off-white | [Sequence]
{D-F5 Phe}-Gln-Trp-{D-Ala}-Val-Ala-His-Leu-OMe |
| Hazard Information | Back Directory | [Uses]
BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC50s in the nanomolar range. BIM-26226 can be used for the research of cancer[1][2]. | [References]
[1] Dietrich JB, et, al. Effects of BIM26226, a potent and specific bombesin receptor antagonist, on amylase release and binding of bombesin-like peptides to AR4-2J cells. Regul Pept. 1994 Oct 21;53(3):165-73. DOI:10.1016/0167-0115(94)90165-1
[2] Damgé C, et, al. Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma. Eur J Pharmacol. 1998 Apr 17;347(1):77-86. DOI:10.1016/s0014-2999(98)00088-0 |
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