| Identification | Back Directory | [Name]
Isophysalin A | [CAS]
1363398-67-7 | [Synonyms]
Isophysalin A
PubChem ID: 57387832
1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,12,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,6a,10b-trimethyl-3-methylene-, (1S,2S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aS)- | [Molecular Formula]
C28H30O10 | [MOL File]
1363398-67-7.mol | [Molecular Weight]
526.54 |
| Hazard Information | Back Directory | [Uses]
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity[1]. | [References]
[1] Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77(5):441-7. DOI:10.1016/j.steroids.2011.11.016 |
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