| Chemical Properties | Back Directory | [Boiling point ]
551.3±52.0 °C(predicted) | [density ]
1.239±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.70±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
BuChE-IN-12 is a selective BuChE inhibitor (IC50=0.52 μM) that acts via affecting CAS and PAS sites and has potential effects against oxidative stress. BuChE-IN-12 can be used in the study of Alzheimer's disease[1]. | [IC 50]
BChE: 0.52 nM (IC50) | [References]
[1] Sadeghian, et al. Synthesis, biological evaluation, molecular docking, and MD simulation of novel 2, 4-disubstituted quinazoline derivatives as selective butyrylcholinesterase inhibitors and antioxidant agents. Scientific Reports 14.1 (2024): 15577. DOI:10.1038/s41598-024-66424-z |
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