| Identification | Back Directory | [Name]
Foropafant | [CAS]
136468-36-5 | [Synonyms]
SR 27417
Foropafant
Faropafant
SR 27417 >=98% (HPLC)
N-(2-Dimethylaminoethyl)-N-(3-pyridylmethyl)-4-(2,4,6-triisopropylphenyl)thiazol-2-amine
4-(2,4,6-Triisopropylphenyl)-N-[2-(dimethylamino)ethyl]-N-(3-pyridylmethyl)thiazol-2-amine
N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2
N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-di
N1,N1-dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-diamine
N,N-Dimethyl-N′-(3-pyridinylmethyl)-N′-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine
N1,N1-Dimethyl-N2-(3-pyridinylmethyl)-N2-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine
1,2-Ethanediamine, N1,N1-dimethyl-N2-(3-pyridinylmethyl)-N2-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]- | [Molecular Formula]
C28H40N4S | [MDL Number]
MFCD00904759 | [MOL File]
136468-36-5.mol | [Molecular Weight]
464.71 |
| Chemical Properties | Back Directory | [Boiling point ]
571.6±60.0 °C(Predicted) | [density ]
1.065±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble5mg/mL (clear solution, warmed) | [form ]
powder | [pka]
8.75±0.28(Predicted) | [color ]
white to beige | [InChI]
1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3 | [InChIKey]
VVBFISAUNSXQGZ-UHFFFAOYSA-N | [SMILES]
CC(C)c1cc(C(C)C)c(-c2csc(n2)N(CCN(C)C)Cc3cccnc3)c(c1)C(C)C |
| Hazard Information | Back Directory | [Uses]
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. | [Biochem/physiol Actions]
SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist. | [References]
[1] Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. DOI:10.1016/j.ejmech.2019.01.043 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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