| Identification | Back Directory | [Name]
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt | [CAS]
136676-91-0 | [Synonyms]
PD 123319 bis(trifluoroacetate)
PD 123319 (trifluoroacetate salt)
PD123319; PD-123319; S-+-PD 123319
PD 123319 DITRIFLUOROACETATE, CID: 6604951
PD 123,319 di(trifluoroacetate) salt hydrate
PD 123,319 hydrate di(trifluoroacetate) salt
PD 123,319 di(trifluoroacetate) salt hydrate powder, >=98% (HPLC)
(S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate)
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt | [Molecular Formula]
C31H32N4O32C2HF3O2 | [MDL Number]
MFCD11046022 | [MOL File]
136676-91-0.mol | [Molecular Weight]
622.65 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble10mg/mL, clear | [form ]
powder | [color ]
White to yellow | [Water Solubility ]
Soluble to 100 mM in water | [InChIKey]
PTSUEYBWHKDYBS-FPCIESGBSA-N | [SMILES]
O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C |
| Hazard Information | Back Directory | [Uses]
PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:
- To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
- To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
- To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.
| [Biological Activity]
PD 123319 ditrifluoroacetate is a potent and selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. | [in vitro]
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125 I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC 50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125 I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC 50 of 6.9 nM , and has a much lower affinity for DuP-753 (IC 50 around 10 microM). | [target]
IC50: 34 nM (AT2 Receptor) | [storage]
Store at -20°C |
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