| Identification | Back Directory | [Name]
Quinolin-3-yl-methanol | [CAS]
13669-51-7 | [Synonyms]
3-quinolylmethanol
3-Quinolinylmethanol
Quinolin-3-yl-methanol
3-(hydroxyMethyl)quinoline | [Molecular Formula]
C10H9NO | [MDL Number]
MFCD03412552 | [MOL File]
13669-51-7.mol | [Molecular Weight]
159.18 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Boiling point ]
329.8±17.0 °C(Predicted) | [density ]
1.218±0.06 g/cm3(Predicted) | [Melting point ]
65-67 °C | [pka]
13.68±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 1: Sodium borohydride (240 mg, 6.4 mmol) was added batchwise to a solution of quinoline-3-carbaldehyde (910 mg, 5.8 mmol) in methanol (10 mL) at room temperature. The reaction mixture was stirred for 3 hours and then the reaction was quenched with saturated aqueous ammonium chloride solution (10 mL). Subsequently, the reaction mixture was extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed with brine and dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford the crude quinolin-3-ylmethanol (795 mg, 86% yield). | [References]
[1] Journal of Organic Chemistry, 1990, vol. 55, # 19, p. 5344 - 5347
[2] European Journal of Organic Chemistry, 2009, # 26, p. 4458 - 4467
[3] Patent: WO2008/115516, 2008, A2. Location in patent: Page/Page column 65
[4] Patent: WO2005/123724, 2005, A1. Location in patent: Page/Page column 73
[5] Heterocycles, 1999, vol. 51, # 8, p. 1883 - 1889 |
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