| Identification | Back Directory | [Name]
NORTRIPTYLINE-D3 HYDROCHLORIDE | [CAS]
136765-48-5 | [Synonyms]
Nortriptyline-d3
Reaxys ID: 2152475
[2H3]-Nortriptyline
NORTRIPTYLINE HCL (D3)
NORTRIPTYLINE HCL (METHYL-D3)
NORTRIPTYLINE-D3 HYDROCHLORIDE
NORTRIPTYLINE-D3 HCL (N-METHYL-D3)
Nortriptyline-D3 hydrochloride solution
NORTRIPTYLINE-D3HYDROCHLORIDE,100/ML(FREEBASE)INMETHANOL
Nortriptyline (D3, 98%) 1.0 mg/ml In Methanol (As Free Base)
NORTRIPTYLINE HCL (D3, 98%) 1.0 MG/ML IN METHANOL (AS FREE BASE)
1-Propanamine, 3-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-ylidene)-N-(methyl-d3)- | [EINECS(EC#)]
802-964-5 | [Molecular Formula]
C19H19ClD3N | [MDL Number]
MFCD00198172 | [MOL File]
136765-48-5.mol | [Molecular Weight]
302.86 |
| Chemical Properties | Back Directory | [Fp ]
9℃ | [storage temp. ]
-20°C | [form ]
liquid | [Major Application]
clinical testing | [InChI]
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H/i1D3; | [InChIKey]
SHAYBENGXDALFF-NIIDSAIPSA-N | [SMILES]
[2H]C([2H])([2H])NCCC=C1C2=C(C=CC=C2)CCC3=C1C=CC=C3.[H]Cl |
| Safety Data | Back Directory | [Hazard Codes ]
F,T | [Risk Statements ]
11-23/24/25-39/23/24/25 | [Safety Statements ]
7-16-36/37-45 | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
2 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| Hazard Information | Back Directory | [Uses]
- Mass spectrometry standard: Nortriptyline-D3 hydrochloride solution is utilized as a high-precision internal standard in mass spectrometry to quantify nortriptyline levels in biological samples, essential for clinical pharmacokinetic studies and therapeutic drug monitoring.
- Metabolite research: As a stable isotope-labeled nortriptyline, it aids in metabolite profiling, helping researchers identify and quantify nortriptyline metabolites in various matrices, which is crucial for understanding drug metabolism and disposition.
- Pharmacokinetic studies: The solution is applied in pharmacokinetic research to assess the absorption, distribution, metabolism, and excretion (ADME) of nortriptyline, providing insights into the drugμs efficacy and safety profiles.
- Quantitative analysis: In bioanalytical research, Nortriptyline-D3 hydrochloride serves as a standard in developing and validating analytical methods, ensuring accuracy and reproducibility in the quantification of nortriptyline in pharmaceutical formulations and clinical samples.
| [General Description]
Nortriptyline is a second generation tricyclic antidepressant (TCA) marketed under trade names such as Sensoval, Aventyl?, and Pamelor? for treatment of major depression. Nortriptyline is also an active metabolite of the TCA amitriptyline. This certified Snap-N-Spike? Solution is suitable as an internal standard for quantitation of nortriptyline levels by LC/MS or GC/MS in clinical toxicology, forensic analysis, urine drug testing, isotope dilution methods, or medication monitoring applications. |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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