| Identification | Back Directory | [Name]
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] | [CAS]
136834-22-5 | [Synonyms]
Bz-2'-F-dA Phosphoramidite
Dmt-2'fluoro-da(bz) amidite
2'-F-N6-Bz-dA phosphoramidite
2'-F-dA(Bz)-CE Phosphoramidite
5'-DMT-2'-F-Bz-dA Phosphoramidite
DMT-2'-F-dA(Bz)-CE Phosphoramidite
N6-Bz-5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite
5'-Dimethoxytrityl-N-Benzoyl-2'-fluoro-3'-[(2-cyanoethyl)-(N,Ndiisopropyl)]-phosphoramidite-deoxyadenosine
N6-Benzoyl-5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diiso-propyl)]phosphoramidite
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite, >97% | [Molecular Formula]
C47H51FN7O7P | [MDL Number]
MFCD12912392 | [MOL File]
136834-22-5.mol | [Molecular Weight]
875.92 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [form ]
Powder | [pka]
7.87±0.43(Predicted) | [color ]
White to off-white | [InChIKey]
ZDIBABNMVQPXHU-JWQXGDSTNA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White to Light yellow powder to crystal. | [Uses]
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA inhibitors. | [Synthesis]
3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.
| [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Adamas Reagent, Ltd.
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4006009262 13023226327 |
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http://www.tansoole.com |
| Company Name: |
T&W GROUP
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021-61551611 13296011611 |
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www.trustwe.com/ |
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