| Identification | Back Directory | [Name]
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide | [CAS]
136941-70-3 | [Synonyms]
Calcium channel-modulator-1
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-[3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl] 5-methyl ester | [Molecular Formula]
C26H24Cl2N2O7S | [MDL Number]
MFCD00905721 | [MOL File]
136941-70-3.mol | [Molecular Weight]
579.45 |
| Chemical Properties | Back Directory | [Boiling point ]
721.2±70.0 °C(Predicted) | [density ]
1.427±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.62±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM. | [in vivo]
Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine[1]. | [References]
[1] Sunkel CE, et al. Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 Jun 26;35(13):2407-14. DOI:10.1021/jm00091a008 |
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