| Identification | Back Directory | [Name]
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- | [CAS]
1370363-74-8 | [Synonyms]
CO23
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]- | [Molecular Formula]
C19H18I2N2O4 | [MDL Number]
MFCD32215345 | [MOL File]
1370363-74-8.mol | [Molecular Weight]
592.17 |
| Chemical Properties | Back Directory | [density ]
1.878±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
8.70±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1]. | [in vivo]
CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1]. | Animal Model: | Hypothyroid Wistar rats[1] | | Dosage: | 0.04, 0.8, 2.5, and 5.0 nmol/g | | Administration: | Ip | | Result: | Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
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| [References]
[1] Grijota-Martínez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42. DOI:10.1210/en.2010-0813 |
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