| Identification | Back Directory | [Name]
Voriconazole | [CAS]
137234-71-0 | [Synonyms]
AMYMCJHOGKVJHB-CRFUWKMFSA-N
Voriconazole camphor sulfonate
(2R, 3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidine-4yl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol camphor sulfonate
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-camphorsulfonate
(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate(for Voriconazole)
4-PyriMidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-, (αR,βS)-, Mono[(1R,4S)-7,7-diMethyl-2-oxobicyclo[2.2.1]heptane-1-Methanesulfonate] (salt) | [Molecular Formula]
C26H30F3N5O5S | [MOL File]
137234-71-0.mol | [Molecular Weight]
581.61 |
| Hazard Information | Back Directory | [Uses]
Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2]. | [in vivo]
Voriconazole (5-20 mg/kg; p.o. for 21 days) camphorsulfonate prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) camphorsulfonate decreases the fungal burden in the lungs[3]. | Animal Model: | Male specific-pathogen-free BALB/cByJ mice[3] | | Dosage: | 1, 5, 20 mg/kg/day | | Administration: | P.o. once daily for 21 days | | Result: | Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.
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| [References]
[1] Nickie D Greer. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8. DOI:10.1080/08998280.2003.11927910
[2] Lesley J Scott, et al. Voriconazole : a review of its use in the management of invasive fungal infections.Drugs. 2007;67(2):269-98. DOI:10.2165/00003495-200767020-00009
[3] A M Sugar,et al. Efficacy of voriconazole in treatment of murine pulmonary blastomycosis.Antimicrob Agents Chemother. 2001 Feb;45(2):601-4. DOI:10.1128/AAC.45.2.601-604.2001 |
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