| Identification | Back Directory | [Name]
3-CHLORO-4-METHOXYBENZALDEHYDE | [CAS]
13726-16-4 | [Synonyms]
AKOS B029259
CHEMBRDG-BB 6945816
TIMTEC-BB SBB003854
3-CHLORO-P-ANISALDEHYDE
3-CHLORO-4-METHOXYBENZALDEHYDE
3-Methoxy-4-chlorobenzaldehyde
Benzaldehyde, 4-chloro-3-methoxy-
3-CHLORO-4-METHOXYBENZENECARBALDEHYDE | [Molecular Formula]
C8H7ClO2 | [MDL Number]
MFCD00016601 | [MOL File]
13726-16-4.mol | [Molecular Weight]
170.59 |
| Chemical Properties | Back Directory | [Melting point ]
56-60 °C(lit.)
| [Boiling point ]
265℃ | [density ]
1.244 | [Fp ]
118℃ | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
Powder | [color ]
White to pale brown |
| Hazard Information | Back Directory | [Synthesis]
D. General procedure for synthesizing 4-chloro-3-methoxybenzaldehyde: Manganese dioxide (5.65 g, 65 mmol) was added to a solution of (4-chloro-3-methoxyphenyl)methanol (5.08 g, 29.4 mmol) in benzene (120 mL). The reaction mixture was refluxed for 17 h. After cooling, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with dichloromethane (300 mL). The filtrate was concentrated under reduced pressure to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89% yield). | [References]
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4408 - 4414
[2] Patent: US2002/77486, 2002, A1
[3] Patent: US6906063, 2005, B2
[4] Patent: EP2314593, 2016, B1. Location in patent: Paragraph 0202
[5] Tetrahedron Letters, 2005, vol. 46, # 32, p. 5417 - 5419 |
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