| Identification | Back Directory | [Name]
EML4-ALK kinase inhibitor 1 | [CAS]
1373409-08-5 | [Synonyms]
EML4-?ALK kinase inhibitor 1
2-Pyrazinecarboxamide, 6-ethyl-5-[(trans-4-methoxycyclohexyl)amino]-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]- | [Molecular Formula]
C31H48N8O3 | [MDL Number]
MFCD32062673 | [MOL File]
1373409-08-5.mol | [Molecular Weight]
580.76 |
| Chemical Properties | Back Directory | [Boiling point ]
702.9±60.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.44±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM[1]. | [References]
[1] Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-169 DOI:10.1016/j.bmc.2019.03.018 |
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