| Identification | Back Directory | [Name]
HYPERCALCEMIA OF MALIGNANCY FACTOR (107-139) (HUMAN) | [CAS]
137348-10-8 | [Synonyms]
PTHrP (107-139)
PTH-RELATED PROTEIN (107-139) (HUMAN)
parathyroidhormone-relatedprotein-(107-139
hypercalcemia of malignancy factor*fragment 107-1
HYPERCALCEMIA OF MALIGNANCY FACTOR FRAGMENT 107-139
HYPERCALCEMIA OF MALIGNANCY FACTOR (107-139) (HUMAN)
HypercalceMia of Malignancy Factor (107-139) (huMan), pTH-Related Protein (107-139) (huMan)
Osteostatin (huMan)
HypercalceMia of Malignancy Factor (107-139) (huMan), pTH-Related Protein (107-139) (huMan)
H-THR-ARG-SER-ALA-TRP-LEU-ASP-SER-GLY-VAL-THR-GLY-SER-GLY-LEU-GLU-GLY-ASP-HIS-LEU-SER-ASP-THR-SER-THR-THR-SER-LEU-GLU-LEU-ASP-SER-ARG-OH
Parathyroid hormone-related protein (107-139), PTHrP (107-139), Thr-Arg-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-Arg
L-Arginine, L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-... | [Molecular Formula]
C142H228N42O58 | [MDL Number]
MFCD00166840 | [MOL File]
137348-10-8.mol | [Molecular Weight]
3451.58 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [Sequence]
Thr-Arg-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-Arg |
| Hazard Information | Back Directory | [Uses]
Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1]. | [References]
[1] Lidia Ibá?ez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[2] C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371. DOI:10.1016/j.actbio.2019.03.033 |
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