| Identification | Back Directory | [Name]
SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA | [CAS]
137348-11-9 | [Synonyms]
SUBSTANCE P ACETATE SALT HYDRATE
Substance P hydrate acetate salt
SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA
SUBSTANCE P ACETATE SALT HYDRATE, BIOCHEMIKA USP/EP/BP | [EINECS(EC#)]
251-545-8 | [Molecular Formula]
C65H102N18O15S | [MOL File]
137348-11-9.mol | [Molecular Weight]
1407.7 |
| Hazard Information | Back Directory | [Uses]
Substance P acetate salt hydrate has been:
- used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
- administered in central nucleus (ACE) in rat to study its positive reinforcing effects
- used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat
| [General Description]
Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group. | [Biochem/physiol Actions]
NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents. |
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Merck KGaA
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SIGMA-RBI
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