| Hazard Information | Back Directory | [Description]
DMJ-I-228 is a specific inhibitor of HIV-1 entry through interaction with the Env spike by virtue of the incorporation of a guandinium group. | [Uses]
DMJ-I-228 is a CD4-mimetic. DMJ-I-228 binds to HIV-1 gp120 within the conserved Phe 43 cavity near the CD4-binding site, thereby blocking CD4 binding and inhibiting HIV-1 infection[1]. | [IC 50]
HIV-1 | [References]
[1] Madani N, et al. CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol. 2014 Jun;88(12):6542-55. DOI:10.1128/JVI.00540-14 |
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