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1374240-01-3

1374240-01-3 Structure

1374240-01-3 Structure
IdentificationBack Directory
[Name]

Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(3aR,7aR)-octahydro-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-6H-pyrrolo[2,3-c]pyridin-6-yl]-
[CAS]

1374240-01-3
[Synonyms]

BTK-IN-19
Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(3aR,7aR)-octahydro-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-6H-pyrrolo[2,3-c]pyridin-6-yl]-
[Molecular Formula]

C21H22Cl2N6O
[MOL File]

1374240-01-3.mol
[Molecular Weight]

445.35
Chemical PropertiesBack Directory
[density ]

1.460±0.06 g/cm3(Predicted)
[pka]

13.33±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

BTK-IN-19 (Compound 51) is a reversible BTK inhibitor with an IC50 of <0.001 μM[1].
[in vivo]

BTK-IN-19 (Compound 51) (80 mg/kg; i.p.; once) inhibits CD69 in mice[1].
BTK-IN-19 (5 mg/kg; p.o.) demonstrates low-moderate in vivo clearance and modest oral exposure (%F > 34) in rats[1].

Animal Model:DBA/1 mice[1]
Dosage:80 mg/kg
Administration:IP, once
Result:Demonstrated strong inhibition of CD69.
[References]

[1] Vandeveer GH, et al. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model. Bioorg Med Chem Lett. 2022 Dec 17;80:129108. DOI:10.1016/j.bmcl.2022.129108
1374240-01-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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