| Identification | Back Directory | [Name]
Pyrimidine, 2-[4-(2-pyrazinyl)-1-piperazinyl]- | [CAS]
137448-39-6 | [Synonyms]
WAY-638944
HIV-1 inhibitor-47
2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine
Pyrimidine, 2-[4-(2-pyrazinyl)-1-piperazinyl]-
1-(Pyrazine-2-yl)-4-(pyrimidine-2-yl)piperazine | [Molecular Formula]
C12H14N6 | [MOL File]
137448-39-6.mol | [Molecular Weight]
242.28 |
| Chemical Properties | Back Directory | [Melting point ]
105.5-106 °C | [Boiling point ]
467.1±55.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.87±0.33(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3]. | [References]
[1] Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19539-44. DOI:10.1073/pnas.0906652106
[2] Becker Irwin. Preparation of derivatives of 1-(2-pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45(4):1005-1022.
[3] Pubchem: 2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine-BioAssay Results. |
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