| Identification | Back Directory | [Name]
L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine | [CAS]
137530-61-1 | [Synonyms]
BE-16627B
L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine | [Molecular Formula]
C16H29N3O7 | [MDL Number]
MFCD00906998 | [MOL File]
137530-61-1.mol | [Molecular Weight]
375.42 |
| Hazard Information | Back Directory | [Description]
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM. |
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| Company Name: |
CHEMICAL LAND21
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| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
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