| Identification | Back Directory | [Name]
GR 64349 | [CAS]
137593-52-3 | [Synonyms]
GR 64349
GR-64349
(GR64349)
LYS-ASP-SER-PHE-VAL-GLY-R-GAMMA-LACTAM-LEU-MET-NH2
[LYS3, GLY8-R-GAMMA-LACTAM-LEU9]NEUROKININ A (3-10)
L-lysyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(αS,3R)-3-amino-α-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-L-methioninamide
L-Methioninamide,L-lysyl-L-a-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(aS,3R)-3-amino-a-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-
L-Methioninamide, L-lysyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(αS,3R)-3-amino-α-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-
L-Lys-L-Asp-L-Ser-L-Phe-L-Val-N-[(3R)-1-[(R)-1-[[[(S)-1-(Aminocarbonyl)-3-(methylthio)propyl]amino]carbonyl]-3-methylbutyl]-2-oxo-3α-pyrrolidinyl]-NH2 | [Molecular Formula]
C42H68N10O11S | [MDL Number]
MFCD00153800 | [MOL File]
137593-52-3.mol | [Molecular Weight]
921.11 |
| Chemical Properties | Back Directory | [Boiling point ]
1342.8±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble to 1 mg/ml in 20% ethanol / water | [form ]
Powder | [pka]
4.13±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Lys-Asp-Ser-Phe-Val-{Aaa}-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
GR 64349 acts as a potent and selective agonist at the NK-2 tachykinin receptor. Initiates changes in the colon, intestine and spinal cord. | [Biological Activity]
GR 64349 peptide acts as an agonist of neurokinin (NK2) receptorwhich leads to reduced NK2 response to kainate and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)but not to NMDA (N-methyl-D-aspartate). | [storage]
Store at -20°C |
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