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137642-54-7

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137642-54-7 Structure

137642-54-7 Structure

Identification	Back Directory
[Name] AM-1220
[CAS] 137642-54-7
[Synonyms] AM-1220 [1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]-naphthalen-1-ylmethanone [1-[(1-Methyl-2-piperidinyl)Methyl]-1H-indol-3-yl]-1-naphthalenylMethanone (1-((1-Methylpiperidin-2-yl)Methyl)-1H-indol-3-yl)(naphthalen-1-yl)Methanone Methanone, [1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-1-naphthalenyl-
[Molecular Formula] C26H26N2O
[MDL Number] MFCD00947094
[MOL File] 137642-54-7.mol
[Molecular Weight] 382.5

Chemical Properties	Back Directory
[Boiling point ] 575.6±20.0 °C(Predicted)
[density ] 1.17
[solubility ] DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 0.15 mg/ml; Methanol: 1 mg/ml
[form ] A crystalline solid
[pka] 9.75±0.10(Predicted)

Safety Data	Back Directory
[Symbol(GHS) ] GHS08
[Signal word ] Warning
[Hazard statements ] H361-H373
[Precautionary statements ] P201-P202-P260-P280-P308+P313-P314-P405-P501

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[Description] AM1220 is a potent synthetic cannabinoid (CB) with preference for the central CB₁ receptor (K_i = 3.88 nM) over the CB₂ receptor (K_i = 73.4 nM). The physiological actions and metabolism of AM1220 have not been characterized.
[Uses] AM-1220 is a synthetic cannabimimetic indole derivative. AM-1220 acts as a potent and moderately selective agonist for the cannabinoid receptor CB1 with around 19 times the selectivity for CB1 over CB2 receptor.

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