| Identification | Back Directory | [Name]
CYCLO(ARG-GLY-ASP-D-PHE-VAL) | [CAS]
137813-35-5 | [Synonyms]
cRGDfV
EMD 66203
CYCLO(RGDD-FV)
EMD 66203, c(RGDfV)
RGDFV PEPTIDE, CYCLIC
Cyclo(Arg-Gls-Asp-D-Phe-Val)
CYCLO(ARG-GLY-ASP-D-PHE-VAL)
Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt
Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl)
Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem | [Molecular Formula]
C26H38N8O7 | [MDL Number]
MFCD00274410 | [MOL File]
137813-35-5.mol | [Molecular Weight]
574.63 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
1 N acetic acid: 5mg/mL | [form ]
White solid | [pka]
4.01±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1]. | [General Description]
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation. | [Biochem/physiol Actions]
Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates | [References]
[1] Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284. DOI:10.3892/ol.2016.5042 |
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| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
| Company Name: |
Binhai gill polypeptide co. LTD
|
| Telephone: |
021-61263389 13524856427 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList326362/0_EN.htm |
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