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1379604-70-2

1379604-70-2 Structure

1379604-70-2 Structure
IdentificationBack Directory
[Name]

(1-hexyl-5-hydroxyindol-3-yl)-naphthalen-1-ylmethanone
[CAS]

1379604-70-2
[Synonyms]

(1-hexyl-5-hydroxyindol-3-yl)-naphthalen-1-ylmethanone
(1-hexyl-5-hydroxy-1H-indol-3-yl)(naphthalen-1-yl)-methanone
Methanone, (1-hexyl-5-hydroxy-1H-indol-3-yl)-1-naphthalenyl-
[Molecular Formula]

C25H25NO2
[MOL File]

1379604-70-2.mol
[Molecular Weight]

371.47
Chemical PropertiesBack Directory
[solubility ]

DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.15 mg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

JWH 019 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB) and the peripheral CB receptors.1 It has been detected in certain herbal blends sold for human consumption. JWH 019 5-hydroxyindole metabolite is expected to be a major metabolite of JWH 019, detectable in serum and urine.2,3 The biological effects of the metabolite are not known
[References]

1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
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