| Identification | Back Directory | [Name]
1H-Naphtho[2,3-c]pyran-8,9-dione, 3-[(1E)-1,3-dimethyl-1-penten-1-yl]-10-hydroxy-7-methoxy-, (-)- | [CAS]
138039-33-5 | [Synonyms]
1H-Naphtho[2,3-c]pyran-8,9-dione, 3-[(1E)-1,3-dimethyl-1-penten-1-yl]-10-hydroxy-7-methoxy-, (-)- | [Molecular Formula]
C21H22O5 | [MOL File]
138039-33-5.mol | [Molecular Weight]
354.4 |
| Hazard Information | Back Directory | [Uses]
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC50 value of 3.2 μM. Anti-tumor agent[1]. | [References]
[1] Soichiro Nishimura, et al. Cell-based screening of extracts of natural sources to search for inhibitors of the ubiquitin-proteasome system and identification of proteasome inhibitors from the fungus Remotididymella sp. Bioorg Med Chem Lett. 2022 Ma DOI:10.1016/j.bmcl.2022.128566 |
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