| Identification | Back Directory | [Name]
C 1311 | [CAS]
138154-39-9 | [Synonyms]
C 1311
XLS-002
Symadex
Symadex >=98% (HPLC)
CUNDRHORZHFPLY-UHFFFAOYSA-N
5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one | [Molecular Formula]
C20H22N4O2 | [MDL Number]
MFCD00947296 | [MOL File]
138154-39-9.mol | [Molecular Weight]
350.41 |
| Chemical Properties | Back Directory | [Boiling point ]
605.8±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL (clear solution; warmed) | [form ]
powder | [pka]
8.35±0.20(Predicted) | [color ]
white to beige | [InChI]
1S/C20H22N4O2/c1-3-23(4-2)10-9-21-15-6-7-16-19-18(15)20(26)14-11-13(25)5-8-17(14)24(19)12-22-16/h5-8,11-12,21,25H,3-4,9-10H2,1-2H3 | [InChIKey]
CUNDRHORZHFPLY-UHFFFAOYSA-N | [SMILES]
CCN(CC)CCNc1ccc2ncn3-c4ccc(O)cc4C(=O)c1c23 |
| Hazard Information | Back Directory | [Uses]
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe[1]. | [Biological Activity]
Symadex is an FMS-like tyrosine kinase 3 (FLT3) and topoisomerase-II inhibitor; ABCG2 substrate; cell cycle modulator. | [References]
[1] Magdalena Hyzy, et al. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005 Mar 1;69(5):801-9. DOI:10.1016/j.bcp.2004.11.028 |
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Energy Chemical
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Merck KGaA
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Alfa Chemistry
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