| Identification | Back Directory | [Name]
(2R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol | [CAS]
1382486-90-9 | [Synonyms]
(R)-FTY720-OME
(2R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol | [Molecular Formula]
C20H35NO2 | [MDL Number]
MFCD28143604 | [MOL File]
1382486-90-9.mol | [Molecular Weight]
321.497 |
| Chemical Properties | Back Directory | [Boiling point ]
464.5±45.0 °C(Predicted) | [density ]
0.980±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
liquid | [pka]
12.51±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
(R)-FTY720-OMe is the analogue of FTY720.
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity. | [Definition]
ChEBI: (2R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol is a 2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol that has R-configuration. It is a sphingosine kinase-2 inhibitor. It has a role as an EC 2.7.1.91 (sphingosine kinase) inhibitor. | [General Description]
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity. | [Biochem/physiol Actions]
(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential. |
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