| Identification | Back Directory | [Name]
S-Cyclopropylglycine Methyl ester hydrochloride | [CAS]
138326-68-8 | [Synonyms]
L-Cyclopropylglycine-OMe.HCl
methyl (2S)-2-amino-2-cyclopropylacetate
Methyl (S)-a-amino-cyclopropaneacetate HCl
(S)-Methyl-2-amino-2-cyclopropylacetate.HCl
S-Cyclopropylglycine Methyl ester hydrochloride
L-Cyclopropylglycine methyl ester hydrochloride
S-2-Cyclopropylglycine methyl ester hydrochloride
Methyl (2S)-amino(cyclopropyl)-acetate hydrochloride
(S)-Methyl 2-amino-2-cyclopropylacetate hydrochloride
S-Cyclopropylglycine Methyl ester hydrochloride USP/EP/BP
Cyclopropaneacetic acid, α-amino-, methyl ester, hydrochloride (1:1), (αS)- | [Molecular Formula]
C6H12ClNO2 | [MDL Number]
MFCD09607984 | [MOL File]
138326-68-8.mol | [Molecular Weight]
165.62 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid | [Optical Rotation]
98.128°(C=0.46 g/100mI, MEOH , 20°C, 589nm) |
| Hazard Information | Back Directory | [Synthesis]
(S)-2-Amino-2-cyclopropylacetic acid (10.0 g, 86.9 mmol) was slowly added to a solution of anhydrous methanol (750 mL) containing thionyl chloride (7.6 mL, 104 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to give the crude product. The crude product was washed with acetone to yield 8.94 g of L-cyclopropylglycine methyl ester hydrochloride as a white solid. The yield was 62% and the mass spectrum (MS) showed a molecular ion peak of 130 (M+H+) and a melting point of 134.0-135.9 °C. | [References]
[1] Patent: US2004/77646, 2004, A1. Location in patent: Page 88
[2] Patent: US2004/248949, 2004, A1. Location in patent: Page 33
[3] Journal of the American Chemical Society, 2015, vol. 137, # 5, p. 2042 - 2046
[4] Patent: US2018/110824, 2018, A1. Location in patent: Paragraph 0642; 0643; 0644 |
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