ChemicalBook--->CAS DataBase List--->1383420-08-3

1383420-08-3

1383420-08-3 Structure

1383420-08-3 Structure
IdentificationBack Directory
[Name]

Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)-
[CAS]

1383420-08-3
[Synonyms]

CRV431
Rencofilstat
Cyclosporin A, 6-[(2S,3R,4R)-10-(acetylamino)-3-hydroxy-4-methyl-2-(methylamino)decanoic acid]-8-(N-methyl-D-alanine)-
[Molecular Formula]

C67H122N12O13
[MOL File]

1383420-08-3.mol
[Molecular Weight]

1303.76
Chemical PropertiesBack Directory
[Boiling point ]

1362.6±65.0 °C(Predicted)
[density ]

1.017±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

13.33±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Rencofilstat (CRV431) is a pan-cyclophilin inhibitor with IC50 values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease[1].
[in vivo]

Rencofilstat (50 mg/kg, po, daily for 8 weeks) exhibits anti-fibtosis and antitumor activities in the mouse nonalcoholic steatohepatitis (NASH) model[1].

Animal Model:Mouse nonalcoholic steatohepatitis (NASH) model[1]
Dosage:50 mg/kg
Administration:po, daily for 8 weeks
Result:Decreased liver fibrosis, reduced the number and size of liver tumors.
[IC 50]

Cyclophilin A: 2.5 nM (IC50); Cyclophilin B: 3.1 nM (IC50); Cyclophilin D: 2.8 nM (IC50); Cyclophilin G: 7.3 nM (IC50)
[References]

[1] Joseph Kuo, et al. A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.
1383420-08-3 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:1383420-08-3 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.