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1383567-59-6

1383567-59-6 Structure

1383567-59-6 Structure
IdentificationBack Directory
[Name]

Bis-PEG13-PFP ester
[CAS]

1383567-59-6
[Synonyms]

Bis-PEG13-PFP ester
4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetracontanedioic acid, 1,43-bis(2,3,4,5,6-pentafluorophenyl) ester
[Molecular Formula]

C42H56F10O17
[MDL Number]

MFCD20926400
[MOL File]

1383567-59-6.mol
[Molecular Weight]

1022.87
Chemical PropertiesBack Directory
[Boiling point ]

817.3±65.0 °C(Predicted)
[density ]

1.312±0.06 g/cm3(Predicted)
[solubility ]

Soluble in DMSO, DCM, DMF
Hazard InformationBack Directory
[Description]

Bis-PEG13-PFP ester is a PEG linker with two activated PFP ester moieties. PFP esters can react with amine groups to form amide bonds. They are also less susceptible to undergo hydrolysis compared to other amine reactive groups. The hydrophilic PEG linker increase the water solubility of the compond in aqueous media.
[Uses]

Bis-PEG13-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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