| Identification | Back Directory | [Name]
ICI D 6888 | [CAS]
138620-17-4 | [Synonyms]
ZD6888
ZD-6888
ZD 6888
ICI D 6888
ICI-D-6888
ZD-6888 HCl
ZD-6888 Hydrochloride
ZD 6888 Hydrochloride,ZD6888 Hydrochloride | [Molecular Formula]
C25H26ClN5O | [MOL File]
138620-17-4.mol | [Molecular Weight]
447.97 |
| Hazard Information | Back Directory | [Uses]
ZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function[1]. | [References]
[1] Jackson DG, et al., Histopathological and ultrastructural changes in the juxtaglomerular apparatus of the rat following administration of ZENECA ZD6888 (2-ethyl-5,6,7,8-tetrahydro-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)- methoxy]quinoline), an angiotensin II antagonist. Toxicol Pathol. 1995 Jan-Feb;23(1):7-15. DOI:10.1177/019262339502300102 |
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