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1386982-70-2

1386982-70-2 Structure

1386982-70-2 Structure
IdentificationBack Directory
[Name]

Valine Impurity 144
[CAS]

1386982-70-2
[Synonyms]

Valine Impurity 144
[Molecular Formula]

C26H32O2
[MOL File]

1386982-70-2.mol
[Molecular Weight]

376.53
Chemical PropertiesBack Directory
[Boiling point ]

541.6±30.0 °C(Predicted)
[density ]

1.048±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ]

Solid
[pka]

4.67±0.33(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

(6E)-SR 11302 is a E-isomer of SR 11302. SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE)[1].
[References]

[1] C Huang, et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30. DOI:10.1073/pnas.94.11.5826
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