| Chemical Properties | Back Directory | [Boiling point ]
1217.4±65.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble,Ethanol: soluble | [form ]
A solid | [pka]
12.52±0.20(Predicted) | [Sequence]
Ac-Gln-Pro-Lys-{Lys(Ac)}-AMC |
| Hazard Information | Back Directory | [Uses]
Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin through sirtuin deacetylation[1]. | [Biological Activity]
Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3.1 It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | [storage]
-20°C | [References]
1.Galleano, I., Schiedel, M., Jung, M., et al.A continuous, fluorogenic sirtuin 2 deacylase assay: Substrate screening and inhibitor evaluationJ. Med. Chem.59(3)1021-1031(2017)
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| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
Fuan Bio
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| Tel: |
18178976185 |
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