| Identification | Back Directory | [Name]
H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2 | [CAS]
138764-85-9 | [Synonyms]
PACAP 1-38
PACAP (31-38) (HUMAN, OVINE, RAT)
TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
PACAP-38?(31-38),?human,?mouse,?rat
H-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2
PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 1-38
PACAP-38 (31-38) (HUMAN, CHICKEN, MOUSE, OVINE, PORCINE, RAT)
PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (31-38), HUMAN, OVINE, RAT
PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (31-38) (HUMAN, OVINE, RAT)
L-Lysinamide,L-tyrosyl-L-lysyl-L-glutaminyl-L-arginyl-L-valyl-L-lysyl-L-asparaginyl-
L-Lysinamide, L-tyrosyl-L-lysyl-L-glutaminyl-L-arginyl-L-valyl-L-lysyl-L-asparaginyl- (9CI)
PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-38 (31-38) (HUMAN, CHICKEN, MOUSE, OVINE, PORCINE, RAT)
PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-NH2: FTDSYSRYRKQMAVKKYLAAVL0NH2
Pituitary Adenylate Cyclase Activating Polypeptide-38 (31-38) (huMan, chicken, Mouse, ovine, porcine, rat) , Pituitary Adenylate Cyclase Activating Polypeptide-38 (31-38) (huMan, chicken, Mouse, ovine, porcine, rat) | [Molecular Formula]
C47H83N17O11 | [MDL Number]
MFCD00080053 | [MOL File]
138764-85-9.mol | [Molecular Weight]
1062.27 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
Solid | [pka]
9.96±0.15(Predicted) | [color ]
White to off-white | [Sequence]
Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 |
| Hazard Information | Back Directory | [Uses]
PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research[1][2][3]. | [Biological Activity]
Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP) but with a greater potency for stimulation of adenylyl cyclase. | [References]
[1] Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017. DOI:10.1016/j.peptides.2018.09.005
[2] Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4. DOI:10.1096/fj.05-4812fje
[3] Braas KM, et, al. Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms. Ann N Y Acad Sci. 1996 De DOI:10.1111/j.1749-6632.1996.tb17484.x |
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