| Identification | Back Directory | [Name]
THR-ARG-SER-ALA-TRP | [CAS]
138949-73-2 | [Synonyms]
Osteostain
OSTEOSTATIN
PTHRP (107-111)
THR-ARG-SER-ALA-TRP
H-THR-ARG-SER-ALA-TRP-OH
OSTEOSTATIN (HUMAN, RAT)
PTH-RP (107-111) (HUMAN, RAT)
PTH RELATED PEPTIDE (107-111)
THR-ARG-SER-ALA-TRP USP/EP/BP
PTH-RELATED PROTEIN (107-111) (HUMAN, RAT)
PARATHYROID HORMONE-RELATED PROTEIN (107-111)
PARATHYROID HORMONE RELATED PEPTIDE (107-111)
HYPERCALCEMIA OF MALIGNANCY FACTOR FRAGMENT 107-111
L-Tryptophan, L-threonyl-L-arginyl-L-seryl-L-alanyl-
HYPERCALCEMIA OF MALIGNANCY FACTOR (107-111) (HUMAN, RAT)
PARATHYROID HORMONE RELATED PROTEIN (107-111), HUMAN, RAT
PTH-RP (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)
OSTEOSTATIN (1-5) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)
PTH-RELATED PROTEIN (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)
HYPERCALCEMIA OF MALIGNANCY FACTOR (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT)
Osteostatin, Parathyroid hormone-related protein (107-111), PTHrP (107-111), Thr-Arg-Ser-Ala-Trp
LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE: KHLNSMERVEWLRKKLQDVHNF
Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt H-Thr-Arg-Ser-Ala-Trp-OH trifluoroacetate salt
pTH-Related Protein (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat), HypercalceMia of Malignancy Factor (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat), pTH-rP (107-111) (huMan, bovine, dog, horse, Mouse, rabbit, rat) | [Molecular Formula]
C27H41N9O8 | [MDL Number]
MFCD00133747 | [MOL File]
138949-73-2.mol | [Molecular Weight]
619.67 |
| Hazard Information | Back Directory | [Uses]
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4]. | [in vivo]
Osteostatin (80 or 120 μg/kg,; after the onset of disease s.c. every day for 13 days) decreases the severity of arthritis as well as cartilage and bone degradation[4].
| Animal Model: | Collagen-induced arthritis in male DBA/1 mice[4] | | Dosage: | 80 or 120 μg/kg | | Administration: | After the onset of disease s.c. every day for 13 days | | Result: | Reduced serum IgG2a levels as well as T cell activation, with the downregulation of RORγt+CD4+ T cells and upregulation of FoxP3+CD8+ T cells in lymph nodes.
Decreased the levels of key cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17, and tumor necrosis factor-α in mice paws, whereas enhanced IL-10.
|
| [References]
[1] Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. DOI:10.1210/endo-129-6-3424
[2] Ibá?ez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[3] Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. DOI:10.1016/j.actbio.2009.08.033
[4] Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845. DOI:10.3390/ijms20163845 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|