| Identification | Back Directory | [Name]
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID | [CAS]
139022-25-6 | [Synonyms]
EOS-60803
Imidazo[1,2-a]pyridine-6-...
6-Carboxyimidazo[1,2-a]pyridine
iMidazo[1,2-a]pyridin-6-carboxylic acid
6-imidazo[2,1-f]pyridinecarboxylic acid
imidazo[2,1-f]pyridine-6-carboxylic acid
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID
H-iMidazo[1,2-a]pyridin-6-carboxylic acid
H-iMidazo[1,2-a]pyridine-6-carbo×ylic acid
H-imidazo[1,2-a]pyridine-6-carboxylic acid
Imidazo[1,2-a]pyridine-6-carboxylicacid97%
Imidazole[1,2-a]pyridine-6-carboxylic acid
Imidazo[1,2-a]pyridine-6-carboxylic acid 97%
Imidazo[1,2-A]Pyridine-6-Carboxylic Acid(WX614286)
IMidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride
IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID ISO 9001：2015 REACH | [Molecular Formula]
C8H6N2O2 | [MDL Number]
MFCD07021498 | [MOL File]
139022-25-6.mol | [Molecular Weight]
162.15 |
| Chemical Properties | Back Directory | [Melting point ]
250 | [density ]
1.41 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
0.67±0.41(Predicted) | [color ]
Pale Beige to Light Beige | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C8H6N2O2/c11-8(12)6-1-2-7-9-3-4-10(7)5-6/h1-5H,(H,11,12) | [InChIKey]
ONOJJCTXSDBVSP-UHFFFAOYSA-N | [SMILES]
C12=NC=CN1C=C(C(O)=O)C=C2 |
| Hazard Information | Back Directory | [Uses]
Imidazo[1,2-a]pyridine-6-carboxylic acid is a brown solid that should be stored sealed at room temperature and away from light. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research. | [Synthesis]
Step 2. Imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride (170 g) was dissolved in water (600 mL) and heated until completely dissolved to form a clarified solution. Subsequently, the pH was adjusted to 5-6 by slowly adding 2 M NaOH aqueous solution. the reaction mixture was cooled to 0 °C in an ice-water bath. The precipitate precipitated was collected by vacuum filtration, washed with ethanol and dried under vacuum to afford the target product imidazo[1,2-a]pyridine-6-carboxylic acid (107.2 g, 77% yield) as a light yellow powder. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI+): 1H NMR δ 13.76-12.82 (br, 1H), 9.28 (s, 1H), 8.10 (s, 1H), 7.68 (s, 1H), 7.64-7.56 (m, 2H); MS (ESI+) m/z: 163 [M + H]+. | [References]
[1] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 130
[2] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 81; 82
[3] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 59; 60
[4] Patent: WO2013/130943, 2013, A1. Location in patent: Paragraph 0181 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Tetranov Biopharm
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13526569071 |
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Adamas Reagent, Ltd.
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4006009262 13023226327 |
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http://www.tansoole.com |
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