| Identification | Back Directory | [Name]
H-LYS-LYS-PRO-TYR-ILE-LEU-OH | [CAS]
139026-64-5 | [Synonyms]
KKPYIL
LYS-LYS-PRO-TYR-ILE-LEU
[LYS8,9]-NEUROTENSIN (8-13)
H-LYS-LYS-PRO-TYR-ILE-LEU-OH
(LYS8,LYS9)-NEUROTENSIN (8-13)
(lys-8-psi-ch2nh-lys9)-neurotensin*fragment 8-13
neurotensin, fragment 8-13, [Lys8-psi-(CH2NH)-Lys9] | [Molecular Formula]
C38H64N8O8 | [MDL Number]
MFCD00237193 | [MOL File]
139026-64-5.mol | [Molecular Weight]
760.96 |
| Chemical Properties | Back Directory | [Boiling point ]
1109.7±65.0 °C(Predicted) | [density ]
1.203±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
Solid | [pka]
3.41±0.10(Predicted) | [color ]
White to off-white | [Sequence]
H-Lys-Lys-Pro-Tyr-Ile-Leu-OH |
| Hazard Information | Back Directory | [Uses]
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1]. | [References]
[1] Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544. DOI:10.1021/acschemneuro.9b00390 |
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