| Identification | Back Directory | [Name]
4(5H)-Thiazolone, 5-[(4-chlorophenyl)methylene]-2-[(6-methoxy-2-benzothiazolyl)amino]- | [CAS]
1390616-76-8 | [Synonyms]
Aldose reductase-IN-3
4(5H)-Thiazolone, 5-[(4-chlorophenyl)methylene]-2-[(6-methoxy-2-benzothiazolyl)amino]- | [Molecular Formula]
C18H12ClN3O2S2 | [MOL File]
1390616-76-8.mol | [Molecular Weight]
401.89 |
| Hazard Information | Back Directory | [Uses]
Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis[1]. | [References]
[1] Kousaxidis A, et al. Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis [published online ahead of print, 2021 Aug 4]. Med Chem Res. 2021;1 DOI:10.1007/s00044-021-02778-7 |
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