ChemicalBook--->CAS DataBase List--->139087-53-9

139087-53-9

139087-53-9 Structure

139087-53-9 Structure
IdentificationBack Directory
[Name]

TYRPHOSTIN B48
[CAS]

139087-53-9
[Synonyms]

AG 494
TYRPHOSTIN B48
TYRPHOSTIN AG 494
A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE
ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-
(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE
[Molecular Formula]

C16H12N2O3
[MDL Number]

MFCD00209863
[MOL File]

139087-53-9.mol
[Molecular Weight]

280.28
Chemical PropertiesBack Directory
[Boiling point ]

586.9±50.0 °C(Predicted)
[density ]

1.416±0.06 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

DMSO: soluble
[pka]

8.80±0.35(Predicted)
Safety DataBack Directory
[Safety Statements ]

22-24/25
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

AG 494 is a potent inhibitor of epidermal growth factor receptor (EGF-R). AG 494 has been found to inhibit cell growth even past the restriction point when receptor activation is no longer necessary; in particular AG 494 causes cells to arrest at late G1 and and during S phase.
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