| Identification | Back Directory | [Name]
Lancovutide | [CAS]
1391-36-2 | [Synonyms]
Moli1901
DURAMYCIN
lancovutide
leucopeptin
Duramycin (~90%)
antibioticpa48009
cyclic6-19)-imine
Lancovutide USP/EP/BP
duramycin from streptoverticillium*ci·Namoneus
duramycin from streptoverticillium*cinnamoneus
2-l-lysine-6-(3-aminoalanine)-10-l-phenylalanine-12-l-phenylalanine-ancoveni
L-Lysine, L-cysteinyl-L-lysyl-L-glutaminyl-D-cysteinyl-L-cysteinyl-3-aminoalanyl-L-phenylalanylglycyl-L-prolyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-L-valyl-L-cysteinyl-(3R)-3-hydroxy-L-α-aspartylglycyl-L-asparaginyl-(2S,3S)-2-amino-3-mercaptobutanoyl-, cyclic (6→19)-imine... | [Molecular Formula]
C89H125N23O25S3 | [MDL Number]
MFCD00133301 | [MOL File]
1391-36-2.mol | [Molecular Weight]
2013.28 |
| Chemical Properties | Back Directory | [Melting point ]
271-273 ºC | [density ]
1.0238 (rough estimate) | [refractive index ]
1.6680 (estimate) | [storage temp. ]
2-8°C | [solubility ]
0.1 M HCl: soluble10mg/mL | [form ]
powder | [pka]
3.15±0.11(Predicted) | [color ]
Off-White to Pale Yellow | [Sequence]
Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe-{Abu}-Phe-Val-Cys-Asp-Gly-Asn-{Abu}-Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11) | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Duramycin is a chloride secretion enhancer in airway epithelium. | [in vivo]
Evaluation of [68Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [68Ga]NODAGA-Duramycin. [68Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice[3]. |
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| Company Name: |
Alfa Chemistry
|
| Tel: |
1-516-6625404 |
| Website: |
https://www.alfa-chemistry.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|